Plasma ionized calcium concentration

Ionized calcium concentration and outcome in critical illness.

OBJECTIVE To assess the association of abnormalities of ionized calcium levels with mortality in a heterogeneous cohort of critically ill patients. DESIGN Retrospective, combined clinical and biochemical study. SETTING Four combined medical/surgical intensive care units. PATIENTS Cohort of 7,024 adult critically ill patients. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS We studie...

Ionized calcium

Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.

Cytosolic calcium ([Ca2+]i) is an important mediator of neuronal signal transduction, participating in diverse biochemical reactions that elicit changes in synaptic efficacy, metabolic rate, and gene transcription. Excessive [Ca2+]i also has been implicated as a cause of acute neuronal injury, although measurement of [Ca2+]i in living neurons by fluorescent calcium indicators has not consistent...

pH-adjusted ionized calcium

A mathematical model of parathyroid hormone response to acute changes in plasma ionized calcium concentration in humans.

A complex bio-mechanism, commonly referred to as calcium homeostasis, regulates plasma ionized calcium (Ca(2+)) concentration in the human body within a narrow range which is crucial for maintaining normal physiology and metabolism. Taking a step towards creating a complete mathematical model of calcium homeostasis, we focus on the short-term dynamics of calcium homeostasis and consider the res...